ReviewPMID: 18031173
Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.
BioDrugs, 1999
Sermorelin produced clinically meaningful growth acceleration in GH-deficient children
Content reviewed by clinical research staff
Evidence graded using the PeptideScholar A-D system.
Sermorelin
AFDA Approved
90
Excellent Credibility
FDA ApprovedPrescription RequiredWADA Banned
Sermorelin is the shortest fully functional fragment of GHRH (amino acids 1-29). It was the first GHRH analog approved by the FDA, marketed as Geref for diagnostic and therapeutic use. Geref was subsequently discontinued in the U.S. market, though sermorelin remains available through compounding pharmacies. Geref was subsequently discontinued in the U.S. market, though sermorelin remains available through compounding pharmacies.
Mechanism of Action
Binds GHRH receptors on anterior pituitary somatotrophs, stimulating natural pulsatile GH release. Preserves the physiological GH feedback axis.
Benefits
This content is for informational purposes only and does not constitute medical advice.
Sermorelin - Dosing in Published Research
Reported routes: Subcutaneous injection
FDA-approved dosing was 0.03 mg/kg SC at bedtime for pediatric GH deficiency. Compounded versions used 200-300 mcg SC nightly.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
Side Effects
Discuss Sermorelin with a doctor
Sermorelin is FDA-approved and available by prescription. Licensed telehealth providers can evaluate if it's right for you.
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Approved Treatment Routing
Sermorelin in PeptideScholar's approved-treatment dataset
Sermorelin is currently modeled on this site as an approved treatment path for: Diagnosis and treatment of growth hormone deficiency in children. Brand names in the current dataset: Geref.
Validation note: This block reflects the site's current structured treatment data and internal routing logic. It is not a substitute for checking current prescribing, labeling, payer, or local regulatory details.
Treatment Hub
Sermorelin Treatment Guide
Approved product paths, real cost friction, provider routing, and tracker next steps — all in one source-backed hub.
Open treatment hub →Research & Evidence
CohortPMID: 9141536
Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women.
J Clin Endocrinol Metab, 1997
Six months of sermorelin improved lean body mass and reduced body fat in adults with GH insufficiency
Compare Sermorelin With
References
- 1.Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.. BioDrugs, 1999. "Sermorelin produced clinically meaningful growth acceleration in GH-deficient children" [PMID: 18031173]
- 2.Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women.. J Clin Endocrinol Metab, 1997. "Six months of sermorelin improved lean body mass and reduced body fat in adults with GH insufficiency" [PMID: 9141536]
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Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.