Ipamorelin vs Sermorelin: Head-to-Head Comparison
Ipamorelin works on the ghrelin receptor while sermorelin works on the GHRH receptor — two different arms of GH release. Sermorelin has a longer clinical history and was previously FDA-approved for pediatric GH deficiency. Ipamorelin provides cleaner pulses while sermorelin mimics the body's natural GHRH signaling.
Side-by-Side Comparison
| Dimension | Ipamorelin | Sermorelin |
|---|---|---|
| Evidence Level | Phase II clinical trials | Formerly FDA-approved; extensive clinical history |
| FDA Status | Not approved | Previously FDA-approved (withdrawn for commercial reasons, not safety) |
| Mechanism | Ghrelin receptor (GHS-R1a) agonist | GHRH receptor agonist (mimics natural GHRH) |
| Side Effects | Minimal | Injection site pain, facial flushing, headache |
| Half-Life | ~2 hours | ~10-20 minutes (very short) |
| Primary Use | Body composition, anti-aging | GH deficiency, anti-aging |
Peptide Overviews
Ipamorelin
BHuman StudiesIpamorelin is a selective growth hormone secretagogue that stimulates growth hormone release from the pituitary gland without significantly affecting cortisol or prolactin levels.
Sermorelin
AFDA ApprovedSermorelin is the shortest fully functional fragment of GHRH (amino acids 1-29). It was the first GHRH analog approved by the FDA, marketed as Geref for diagnostic and therapeutic use.
Ipamorelin vs Sermorelin: FAQ
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No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.