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Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system

MGF (Mechano Growth Factor)

DLimited Data
30
Low Credibility
1 cited studyy · Evidence level D

IGF-1 splice variant (IGF-1Ec) · 24 amino acids

Not FDA ApprovedWADA Banned

Mechano Growth Factor (MGF) is a splice variant of IGF-1 (specifically IGF-1Ec) that is upregulated in response to mechanical stress and muscle damage. It is believed to play a role in muscle stem cell activation and tissue repair. The synthetic peptide sold as 'MGF' or 'PEG-MGF' is a research chemical with no human clinical data.

Mechanism of Action

The MGF splice variant activates muscle satellite cells (stem cells) and promotes their proliferation and differentiation into new muscle fibers. It also has local anti-inflammatory effects in damaged muscle. PEG-MGF is a pegylated version designed to extend half-life. The mechanism is based on cell culture and animal studies only.

Benefits

  • Activates muscle satellite cells for repair and growth
  • Promotes muscle regeneration after damage in animal models
  • Local anti-inflammatory effects in injured muscle
Not Medical Advice — Research-Reported Information Only

This content is for informational purposes only and does not constitute medical advice.

MGF (Mechano Growth Factor) — Dosing in Published Research

Reported Routes: Subcutaneous injection, Intramuscular injection
No established human dosing. Research chemical suppliers recommend 200-400 mcg subcutaneously into target muscle groups, but this is entirely unvalidated. No pharmacokinetic or safety data exists in humans.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • No human safety data exists
  • Unknown effects on muscle stem cell depletion with chronic use
  • Immunogenicity risk with repeated injections
  • Not approved for human use

Considering Peptide Research?

MGF (Mechano Growth Factor) is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

AnimalArthritis Res Ther, 2025

Mechanical growth factor inhibited syndesmophyte formation and the progression of osteoarthritis and ankylosing spondylitis-like symptoms in HLA-B27/Hu-β2m transgenic rats.

MGF showed anti-inflammatory and tissue-protective effects in a rat model of osteoarthritis and ankylosing spondylitis

PMID: 41272763

References

  1. 1. Mechanical growth factor inhibited syndesmophyte formation and the progression of osteoarthritis and ankylosing spondylitis-like symptoms in HLA-B27/Hu-β2m transgenic rats.. Arthritis Res Ther, 2025. “MGF showed anti-inflammatory and tissue-protective effects in a rat model of osteoarthritis and ankylosing spondylitis” [PMID: 41272763]

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MGF (Mechano Growth Factor) FAQ

Medical Disclaimer

This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.

Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.

No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.

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