Content reviewed by clinical research staff

Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system.

CJC-1295

GHRH analog29 amino acids

BHuman Studies
80
Good Credibility
2 cited studies | Evidence level B

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH). Available in two forms: with and without Drug Affinity Complex (DAC), which extends its half-life.

Mechanism of Action

Binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile growth hormone release. The DAC modification enables albumin binding, extending half-life to 6-8 days.

Benefits

  • Sustained GH elevation for multiple days[1]
  • Increased IGF-1 levels in human subjects[1]
  • Improved deep sleep quality reported[1]
  • Supports lean mass and fat metabolism[1]
Not medical advice - research-reported information only

This content is for informational purposes only and does not constitute medical advice.

CJC-1295 - Dosing in Published Research

Reported routes: Subcutaneous injection
Clinical trial used single SC doses of 30-60 mcg/kg. CJC-1295 without DAC (Mod GRF 1-29) is dosed more frequently.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Flushing and warmth[1]
  • Headache[1]
  • Dizziness[1]
  • Injection site reactions[1]
  • Potential water retention[1]

Considering peptide research?

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Research & Evidence

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References

  1. 1.Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.. J Clin Endocrinol Metab, 2006. "Single SC dose produced sustained 2-10 fold GH increases lasting 6+ days with IGF-1 elevation for 9-11 days" [PMID: 16352683]
  2. 2.Advances in the detection of growth hormone releasing hormone synthetic analogs.. Drug Test Anal, 2021. "Review of analytical methods for detecting GHRH synthetic analogs including CJC-1295 in anti-doping testing" [PMID: 34665524]

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