ReviewPMID: 30980360
Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37.
Adv Exp Med Biol, 2019
Comprehensive review of LL-37 antimicrobial, immunomodulatory, and wound healing functions in human innate immunity
Content reviewed by clinical research staff
Evidence graded using the PeptideScholar A-D system.
LL-37
CPreclinical
70
Good Credibility
Not FDA ApprovedWADA Banned
LL-37 (also written as ll37 or ll-37) is the only cathelicidin antimicrobial peptide found in humans. It plays a crucial role in innate immune defense, wound healing, and inflammation modulation.
Mechanism of Action
Disrupts microbial membranes through electrostatic interaction with negatively charged phospholipids. Also modulates immune cell chemotaxis, inflammatory cytokine release, and promotes angiogenesis.
Benefits
This content is for informational purposes only and does not constitute medical advice.
LL-37 - Dosing in Published Research
Reported routes: Subcutaneous injection, Topical
Research dosing varies widely. Topical wound studies used 1-10 mcg/mL concentrations. No established systemic dosing.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
Side Effects
Considering peptide research?
LL-37 is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.
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Research & Evidence
In VitroPMID: 29737589
LL-37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line.
J Pept Sci, 2018
Review of LL-37 therapeutic applications including chronic wounds, infections, and cancer with discussion of delivery challenges
Compare LL-37 With
References
- 1.Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37.. Adv Exp Med Biol, 2019. "Comprehensive review of LL-37 antimicrobial, immunomodulatory, and wound healing functions in human innate immunity" [PMID: 30980360]
- 2.LL-37 fragments have antimicrobial activity against Staphylococcus epidermidis biofilms and wound healing potential in HaCaT cell line.. J Pept Sci, 2018. "Review of LL-37 therapeutic applications including chronic wounds, infections, and cancer with discussion of delivery challenges" [PMID: 29737589]
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Research Supplies
Equipment for responsible research-grade peptide handling and administration.
Alcohol Prep Pads (200 ct)
Sterile 70% isopropyl pads for injection site preparation — essential for subcutaneous protocols.
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1mL Insulin Syringes (28G)
Thin-gauge 28G syringes for subcutaneous peptide administration with minimal discomfort.
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Sharps Disposal Container (1 Qt)
Biohazard-safe sharps container for responsible disposal of used syringes.
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Digital Milligram Scale (0.001g)
High-precision scale for accurate measurement of peptide powder before reconstitution.
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LL-37 FAQ
Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.