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Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system

TB-500 (Thymosin Beta-4)

CPreclinical

Thymic peptide (synthetic fragment) · 43 amino acids

Not FDA ApprovedWADA Banned

TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4. It plays a role in cell migration, blood vessel formation, and tissue repair.

Mechanism of Action

Sequesters G-actin monomers to promote cell migration and wound healing. Upregulates actin polymerization and activates cardiac progenitor cells.

Benefits

  • Enhanced wound healing and tissue repair in animal studies
  • Reduced cardiac fibrosis after injury in mice
  • Promotes hair regrowth in preclinical models
  • Anti-inflammatory effects observed in vitro
Not Medical Advice — Research-Reported Information Only

This content is for informational purposes only and does not constitute medical advice.

TB-500 (Thymosin Beta-4) — Dosing in Published Research

Reported Routes: Subcutaneous injection
Preclinical research uses variable dosing. No established human dosing protocols from clinical trials.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Limited human safety data
  • Potential headache
  • Injection site irritation
  • Theoretical concern about promoting growth of existing tumors

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TB-500 (Thymosin Beta-4) is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

AnimalFASEB Journal, 2004

Thymosin beta 4 induces hair growth via stem cell migration and differentiation

TB4 stimulated hair growth in normal rats and mice by promoting stem cell migration to hair follicles

PMID: 17947589
ReviewAnnals of the New York Academy of Sciences, 2010

Thymosin beta-4 promotes angiogenesis and wound healing

Review of TB4 mechanisms in angiogenesis and dermal wound repair

PMID: 20811094
AnimalPeptides, 2012

Thymosin beta 4 and cardiac repair

TB4 reduced scarring and improved cardiac function after myocardial infarction in murine models

PMID: 22684907

Compare TB-500 (Thymosin Beta-4) With

TB-500 (Thymosin Beta-4) vs BPC-157
TB-500 (Thymosin Beta-4) vs GHK-Cu
TB-500 (Thymosin Beta-4) vs LL-37

References

  1. 1. Thymosin beta 4 induces hair growth via stem cell migration and differentiation. FASEB Journal, 2004. “TB4 stimulated hair growth in normal rats and mice by promoting stem cell migration to hair follicles” [PMID: 17947589]
  2. 2. Thymosin beta-4 promotes angiogenesis and wound healing. Annals of the New York Academy of Sciences, 2010. “Review of TB4 mechanisms in angiogenesis and dermal wound repair” [PMID: 20811094]
  3. 3. Thymosin beta 4 and cardiac repair. Peptides, 2012. “TB4 reduced scarring and improved cardiac function after myocardial infarction in murine models” [PMID: 22684907]

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Medical Disclaimer

This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.

Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.

No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.

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