GHK-Cu

BHuman Studies

Copper-binding tripeptide · 3 amino acids

Cosmetic Ingredient

GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. Found in human plasma, saliva, and urine, its concentration declines with age.

Mechanism of Action

Binds copper(II) ions and delivers them to tissues. Stimulates collagen, elastin, and glycosaminoglycan synthesis. Activates proteasome activity and modulates gene expression of over 4,000 genes.

Benefits

Clinically demonstrated skin rejuvenation and wrinkle reduction
Accelerated wound healing in human studies
Stimulates collagen and elastin synthesis
Anti-inflammatory and antioxidant activity

Not Medical Advice — Research-Reported Information Only

This content is for informational purposes only and does not constitute medical advice.

GHK-Cu — Dosing in Published Research

Reported Routes: Topical, Subcutaneous injection

Used topically in cosmetic products at concentrations of 0.01-1%. Injectable research doses typically 1-2 mg/day in studies.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

Mild skin irritation with topical use
Temporary skin redness
Rare allergic reactions
Minimal systemic side effects with topical application

Interested in GHK-Cu Products?

GHK-Cu is available in cosmetic formulations. Look for products with clinical-grade copper peptide concentrations.

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Research & Evidence

ReviewBioMed Research International, 2015

GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration

Comprehensive review of GHK-Cu in skin regeneration showing stimulation of collagen, decorin, and glycosaminoglycans

PMID: 25270173

CohortJournal of Peptide Science, 2014

GHK-copper complex and wound healing

GHK-Cu accelerated wound closure and increased angiogenesis in human skin studies

PMID: 24508138

In VitroGene, 2020

Gene expression changes induced by GHK-Cu

GHK-Cu modulated expression of 4,000+ genes related to antioxidant, anti-inflammatory, and repair pathways

PMID: 32719413

Compare GHK-Cu With

GHK-Cu vs BPC-157

GHK-Cu vs TB-500

GHK-Cu vs KPV

References

1. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 2015. “Comprehensive review of GHK-Cu in skin regeneration showing stimulation of collagen, decorin, and glycosaminoglycans” [PMID: 25270173]
2. GHK-copper complex and wound healing. Journal of Peptide Science, 2014. “GHK-Cu accelerated wound closure and increased angiogenesis in human skin studies” [PMID: 24508138]
3. Gene expression changes induced by GHK-Cu. Gene, 2020. “GHK-Cu modulated expression of 4,000+ genes related to antioxidant, anti-inflammatory, and repair pathways” [PMID: 32719413]

Recommended Resources

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Medical Disclaimer

This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.

Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.

No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.