ReviewPMID: 21668043
Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy.
Drugs, 2011
26-week trial showed significant reduction in visceral adipose tissue vs placebo in HIV lipodystrophy
Content reviewed by clinical research staff
Evidence graded using the PeptideScholar A-D system.
Tesamorelin
AFDA Approved
95
Excellent Credibility
FDA ApprovedPrescription RequiredWADA Banned
Tesamorelin is a synthetic GHRH analog approved by the FDA as Egrifta for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.
Mechanism of Action
Binds to GHRH receptors and stimulates pituitary production and release of endogenous growth hormone. The trans-3-hexenoic acid modification increases receptor binding stability.
Benefits
This content is for informational purposes only and does not constitute medical advice.
Tesamorelin - Dosing in Published Research
Reported routes: Subcutaneous injection
FDA-approved dose: 2 mg SC once daily. Treatment should be discontinued if no reduction in visceral fat after 6 months.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
Side Effects
Discuss Tesamorelin with a doctor
Tesamorelin is FDA-approved and available by prescription. Licensed telehealth providers can evaluate if it's right for you.
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Approved Treatment Routing
Tesamorelin in PeptideScholar's approved-treatment dataset
Tesamorelin is currently modeled on this site as an approved treatment path for: Reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Brand names in the current dataset: Egrifta, Egrifta SV.
Validation note: This block reflects the site's current structured treatment data and internal routing logic. It is not a substitute for checking current prescribing, labeling, payer, or local regulatory details.
Treatment Hub
Tesamorelin Treatment Guide
Approved product paths, real cost friction, provider routing, and tracker next steps — all in one source-backed hub.
Open treatment hub →Research & Evidence
Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial.
Lancet HIV, 2019
Tesamorelin reduced hepatic fat fraction by 37% in HIV-infected patients with fatty liver
Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.
Arch Neurol, 2012
Tesamorelin preserved cognitive function and reduced brain amyloid in at-risk adults over 20 weeks
Compare Tesamorelin With
References
- 1.Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy.. Drugs, 2011. "26-week trial showed significant reduction in visceral adipose tissue vs placebo in HIV lipodystrophy" [PMID: 21668043]
- 2.Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial.. Lancet HIV, 2019. "Tesamorelin reduced hepatic fat fraction by 37% in HIV-infected patients with fatty liver" [PMID: 31611038]
- 3.Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.. Arch Neurol, 2012. "Tesamorelin preserved cognitive function and reduced brain amyloid in at-risk adults over 20 weeks" [PMID: 22869065]
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Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.