Content reviewed by clinical research staff

Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system.

GHRP-2

Growth hormone releasing peptide6 amino acids

BHuman Studies
80
Good Credibility
2 cited studies | Evidence level B

GHRP-2 is a synthetic hexapeptide growth hormone secretagogue. It is one of the most potent GHRPs and has been used in clinical research for GH deficiency diagnosis.

Mechanism of Action

Binds ghrelin/GHS receptors in the pituitary and hypothalamus, stimulating GH release. Also stimulates appetite and increases cortisol and prolactin (less selective than ipamorelin).

Benefits

  • Potent GH release in human subjects[1]
  • Used diagnostically for GH deficiency assessment[1]
  • Increases appetite and food intake[1]
  • Improved sleep quality in some studies[1]
Not medical advice - research-reported information only

This content is for informational purposes only and does not constitute medical advice.

GHRP-2 - Dosing in Published Research

Reported routes: Subcutaneous injection, Intravenous
Clinical studies used 1-2 mcg/kg IV or SC. Typically dosed 2-3 times daily in research protocols.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Increased appetite and hunger[1]
  • Elevated cortisol levels[1]
  • Elevated prolactin levels[1]
  • Water retention[1]
  • Flushing[1]

Considering peptide research?

GHRP-2 is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

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References

  1. 1.Growth hormone-releasing peptides.. Eur J Endocrinol, 1997. "GHRP-2 was a potent and reliable GH secretagogue useful for diagnostic testing of GH reserve" [PMID: 9186261]
  2. 2.Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells.. Eur J Endocrinol, 2004. "GHRH + GHRP-2 combination produced synergistic GH release exceeding either agent alone" [PMID: 14763922]

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