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Evidence graded using the PeptideScholar A-D system.
ARA-290 (cibinetide) is a peptide engineered from the structure of erythropoietin (EPO) that selectively activates the Innate Repair Receptor (IRR) without stimulating erythropoiesis. It was developed to harness EPO's tissue-protective and anti-inflammatory properties while avoiding the risks of increased red blood cell production. It has shown promise in Phase 2 clinical trials for neuropathic pain, diabetic complications, and tissue repair.
Selectively binds to the Innate Repair Receptor (IRR), a heterodimer of the erythropoietin receptor (EPOR) and the common beta receptor (βc/CD131). This activates anti-inflammatory, anti-apoptotic, and tissue-protective signaling pathways without triggering erythropoiesis. Promotes small nerve fiber repair, reduces neuroinflammation, and improves metabolic parameters including glucose control.
This content is for informational purposes only and does not constitute medical advice.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
ARA-290 (Cibinetide) is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.
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Invest Ophthalmol Vis Sci, 2017
Phase 2 trial: cibinetide significantly increased corneal nerve fiber area and reduced neuropathic pain scores in sarcoidosis patients
Mol Med, 2015
Randomized trial showing ARA-290 improved HbA1c, lipid profiles, and neuropathic pain scores in T2DM patients
Mol Med, 2013
First clinical demonstration that ARA-290 can reverse small nerve fiber damage in sarcoidosis, with sustained benefit after treatment
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Tools and supplements commonly used alongside healing peptide research protocols.
Deep-Tissue Foam Roller
Self-myofascial release to complement healing peptide protocols for tendons and soft tissue.
Reusable Gel Ice Pack Wrap
Cold therapy reduces local inflammation — commonly used alongside BPC-157 and TB-500 research.
Magnesium Glycinate Capsules
Highly bioavailable magnesium supports muscle recovery, sleep quality, and reduces cramping.
Collagen Peptides Powder
Type I & III hydrolyzed collagen to support tendon, ligament, and joint repair.
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Equipment for responsible research-grade peptide handling and administration.
Alcohol Prep Pads (200 ct)
Sterile 70% isopropyl pads for injection site preparation — essential for subcutaneous protocols.
1mL Insulin Syringes (28G)
Thin-gauge 28G syringes for subcutaneous peptide administration with minimal discomfort.
Sharps Disposal Container (1 Qt)
Biohazard-safe sharps container for responsible disposal of used syringes.
Digital Milligram Scale (0.001g)
High-precision scale for accurate measurement of peptide powder before reconstitution.
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Books covering peptide science, longevity research, and biohacking frameworks.
The Peptide Protocols
Comprehensive reference for peptide mechanisms, dosing research, and clinical applications.
Boundless by Ben Greenfield
Covers peptides, nootropics, hormones, and longevity strategies in an optimization framework.
Lifespan by David Sinclair
Evidence-based deep-dive into aging science, directly relevant to longevity peptide research.
The Longevity Paradox
Gut-centric aging research with diet and supplementation protocols for extending healthspan.
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Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.