Content reviewed by clinical research staff

Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system.

Thymalin

Thymic dipeptide2 amino acids

CPreclinical
70
Good Credibility
2 cited studies | Evidence level C

Thymalin is a synthetic dipeptide (glutamyl-tryptophan) originally derived from calf thymus extract. Developed by Vladimir Khavinson in Russia, it is used there for immune modulation.

Mechanism of Action

Modulates T-cell differentiation and function. Restores thymic function in aged subjects. Regulates cytokine production and immune cell ratios.

Benefits

  • Immune system restoration in elderly patients (Russian studies)[2]
  • Increased T-cell counts in immunocompromised subjects[1]
  • Extended lifespan in animal aging studies[1]
  • Approved and clinically used in Russia[1]
Not medical advice - research-reported information only

This content is for informational purposes only and does not constitute medical advice.

Thymalin - Dosing in Published Research

Reported routes: Intramuscular injection, Subcutaneous injection
Russian clinical protocols use 10 mg IM daily for 5-10 days. Typically administered in courses 1-2 times per year.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Generally well-tolerated in Russian clinical use
  • Mild allergic reactions reported rarely[1]
  • Injection site reactions[1]
  • Limited Western safety data[1]

Considering peptide research?

Thymalin is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

Peptides and Ageing.

Neuro Endocrinol Lett, 2002

Review of peptide geroprotectors including thymalin and epithalamin with discussion of immune modulation and aging research

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References

  1. 1.Peptides and Ageing.. Neuro Endocrinol Lett, 2002. "Review of peptide geroprotectors including thymalin and epithalamin with discussion of immune modulation and aging research" [PMID: 12374906]
  2. 2.[Geroprotective effect of thymalin and epithalamin].. Adv Gerontol, 2002. "Thymalin restored age-related decline in T-cell immunity and normalized cytokine profiles in elderly patients" [PMID: 12577695]

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