Content reviewed by clinical research staff

Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system.

TB-500 (Thymosin Beta-4)

Thymic peptide (synthetic fragment)43 amino acids

CPreclinical
75
Good Credibility
3 cited studies | Evidence level C

TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4. It plays a role in cell migration, blood vessel formation, and tissue repair.

Mechanism of Action

Sequesters G-actin monomers to promote cell migration and wound healing. Upregulates actin polymerization and activates cardiac progenitor cells.

Benefits

  • Enhanced wound healing and tissue repair in animal studies[2]
  • Reduced cardiac fibrosis after injury in mice[3]
  • Promotes hair regrowth in preclinical models[1]
  • Anti-inflammatory effects observed in vitro[1]
Not medical advice - research-reported information only

This content is for informational purposes only and does not constitute medical advice.

TB-500 (Thymosin Beta-4) - Dosing in Published Research

Reported routes: Subcutaneous injection
Preclinical research uses variable dosing. No established human dosing protocols from clinical trials.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Limited human safety data
  • Potential headache[1]
  • Injection site irritation[1]
  • Theoretical concern about promoting growth of existing tumors

Considering peptide research?

TB-500 (Thymosin Beta-4) is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

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References

  1. 1.Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann N Y Acad Sci, 2007. "TB4 stimulated hair growth in normal rats and mice by promoting stem cell migration to hair follicles" [PMID: 17947589]
  2. 2.Thymosin β4 Promotes Dermal Healing.. Vitam Horm, 2016. "Review of TB4 mechanisms in angiogenesis and dermal wound repair" [PMID: 27450738]
  3. 3.Thymosin beta4 and cardiac repair.. Ann N Y Acad Sci, 2010. "TB4 reduced scarring and improved cardiac function after myocardial infarction in murine models" [PMID: 20536454]

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TB-500 (Thymosin Beta-4) FAQ