Survodutide for the Treatment of Obesity: Rationale and Design of the SYNCHRONIZE Cardiovascular Outcomes Trial.
JACC Heart Fail, 2024
Survodutide produced up to 19% weight loss at 46 weeks with significant improvements in cardiometabolic markers
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Evidence graded using the PeptideScholar A-D system.
Survodutide is a dual GLP-1 and glucagon receptor agonist developed by Boehringer Ingelheim. In Phase 3 trials, it demonstrates significant weight loss and is also being investigated for metabolic dysfunction-associated steatohepatitis (MASH/NAFLD).
Dual agonist targeting GLP-1 receptors (appetite suppression, insulin secretion) and glucagon receptors (increased energy expenditure, hepatic lipid metabolism). The glucagon component drives liver fat reduction, differentiating it from GLP-1-only agonists.
This content is for informational purposes only and does not constitute medical advice.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
Survodutide is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.
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JACC Heart Fail, 2024
Survodutide produced up to 19% weight loss at 46 weeks with significant improvements in cardiometabolic markers
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