AOD-9604 vs Ipamorelin: Head-to-Head Comparison
AOD-9604 is an hGH fragment (176-191) that was designed to isolate fat-burning effects of GH without other GH activity, while ipamorelin stimulates natural GH release for full-spectrum GH benefits. AOD-9604 failed clinical trials for obesity, while ipamorelin shows consistent GH elevation in studies.
Side-by-Side Comparison
| Dimension | AOD-9604 | Ipamorelin |
|---|---|---|
| Evidence Level | Failed Phase IIb/III trials for obesity | Phase II trials showing consistent GH release |
| FDA Status | Not approved | Not approved |
| Mechanism | hGH fragment targeting lipolysis without IGF-1 | Ghrelin receptor agonist stimulating natural GH pulses |
| Body Composition Effect | Failed to demonstrate efficacy in trials | GH elevation supports fat loss and lean mass |
| Side Effects | Minimal reported | Minimal; no cortisol/prolactin impact |
| GH/IGF-1 Impact | Does not raise GH or IGF-1 | Raises GH and IGF-1 levels |
| Cost | Low | Moderate |
Peptide Overviews
AOD-9604
CPreclinicalAOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) originally developed for obesity treatment. It received GRAS status from the FDA for use in food products.
Ipamorelin
BHuman StudiesIpamorelin is a selective growth hormone secretagogue that stimulates growth hormone release from the pituitary gland without significantly affecting cortisol or prolactin levels.
AOD-9604 vs Ipamorelin: FAQ
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This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
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No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.