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Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system

Melanotan II

CPreclinical

Melanocortin receptor agonist · 7 amino acids

Not FDA ApprovedWADA Banned

Melanotan II is a synthetic cyclic peptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). Originally developed for skin tanning, it also has sexual arousal effects but significant safety concerns.

Mechanism of Action

Non-selective melanocortin receptor agonist (MC1R through MC5R). MC1R activation causes melanogenesis (tanning). MC4R activation causes sexual arousal. MC3R/4R activation suppresses appetite.

Benefits

  • Produces skin tanning without UV exposure in studies
  • Erectile response observed in male subjects
  • Appetite suppression
  • Precursor compound that led to bremelanotide development
Not Medical Advice — Research-Reported Information Only

This content is for informational purposes only and does not constitute medical advice.

Melanotan II — Dosing in Published Research

Reported Routes: Subcutaneous injection
Research studies used 0.01-0.025 mg/kg SC. Self-administration is widespread but carries significant safety risks due to unregulated products.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Nausea and flushing (very common)
  • Facial flushing
  • Uncontrolled erections
  • New or changing moles (melanocyte stimulation)
  • Increased melanoma risk is a theoretical concern
  • Dangerous with unregulated sources

Considering Peptide Research?

Melanotan II is not FDA-approved. Always consult a licensed healthcare provider before considering any peptide.

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Research & Evidence

RCTInternational Journal of Impotence Research, 1999

Melanotan II and sexual function in males

Melanotan II induced erections in 8 of 10 men with psychogenic erectile dysfunction in a double-blind crossover study

PMID: 10369688
RCTMelanoma Research, 2002

Melanotan II and skin pigmentation

SC Melanotan II significantly increased skin melanin density without UV exposure in fair-skinned subjects

PMID: 11736944

Compare Melanotan II With

Melanotan II vs Bremelanotide

References

  1. 1. Melanotan II and sexual function in males. International Journal of Impotence Research, 1999. “Melanotan II induced erections in 8 of 10 men with psychogenic erectile dysfunction in a double-blind crossover study” [PMID: 10369688]
  2. 2. Melanotan II and skin pigmentation. Melanoma Research, 2002. “SC Melanotan II significantly increased skin melanin density without UV exposure in fair-skinned subjects” [PMID: 11736944]

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Medical Disclaimer

This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.

Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.

No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.

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