Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List
Evidence graded using the PeptideScholar A-D system.
Semax
Synthetic ACTH(4-10) analog7 amino acids
BHuman Studies
80
Good Credibility
2 cited studies | Evidence level B
Not FDA ApprovedWADA Banned
Semax is a synthetic peptide derived from the ACTH(4-10) fragment, developed in Russia as a nootropic and neuroprotective agent. It is approved in Russia for stroke, cognitive disorders, and optic nerve disease.
Mechanism of Action
Enhances BDNF and NGF expression. Modulates dopaminergic, serotonergic, and cholinergic neurotransmission. Increases cerebral blood flow and has anti-inflammatory effects in the CNS.
Benefits
Neuroprotective effects in stroke (Russian clinical trials)[1]
Russian approved dosing: 200-600 mcg intranasal daily. Higher doses (up to 1.2 mg) used for acute stroke treatment.
The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.
1.[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)].. Zh Nevrol Psikhiatr Im S S Korsakova, 1997. "Semax improved neurological outcomes and reduced disability when administered within 12 hours of ischemic stroke onset" [PMID: 11517472]
2.The heptapeptide SEMAX stimulates BDNF expression in different areas of the rat brain in vivo.. Dokl Biol Sci, 2003. "Semax upregulated BDNF and NGF expression in rat brain, supporting its neuroprotective mechanism" [PMID: 14556513]
Recommended Resources
The Peptide Protocols Handbook
Evidence-based reference guide covering mechanisms, research, and clinical applications.
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Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
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No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.