Sermorelin vs Tesamorelin: Head-to-Head Comparison
Both are GHRH analogs but tesamorelin is FDA-approved and has Phase III data for visceral fat reduction. Sermorelin was previously FDA-approved for pediatric use and is widely prescribed off-label in anti-aging clinics. Tesamorelin is more potent but substantially more expensive.
Side-by-Side Comparison
| Dimension | Sermorelin | Tesamorelin |
|---|---|---|
| Evidence Level | Formerly FDA-approved; extensive clinical use | Phase III trials; currently FDA-approved |
| FDA Status | Previously approved (withdrawn commercially) | Currently FDA-approved (Egrifta) |
| Mechanism | GHRH(1-29) analog | Modified GHRH analog with enhanced potency |
| Primary Use | GH deficiency, anti-aging | HIV lipodystrophy, visceral fat reduction |
| Half-Life | ~10-20 minutes | ~26-38 minutes |
| Side Effects | Flushing, headache, injection pain | Arthralgia, injection site reactions, edema |
| Cost | Low to moderate (widely compounded) | Very high (brand-name pharmaceutical) |
Peptide Overviews
Sermorelin
AFDA ApprovedSermorelin is the shortest fully functional fragment of GHRH (amino acids 1-29). It was the first GHRH analog approved by the FDA, marketed as Geref for diagnostic and therapeutic use.
Tesamorelin
AFDA ApprovedTesamorelin is a synthetic GHRH analog approved by the FDA as Egrifta for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.
Sermorelin vs Tesamorelin: FAQ
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