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Content reviewed by clinical research staff

Last reviewed: March 2026Sources: PubMed, FDA, WADA Prohibited List

Evidence graded using the PeptideScholar A-D system

Teduglutide

AFDA Approved
65
Moderate Credibility
1 cited studyy · Evidence level A

Glucagon-like peptide-2 (GLP-2) analog · 33 amino acids · Brand: Gattex

FDA ApprovedPrescription Required

Teduglutide is a recombinant analog of human GLP-2 and the first FDA-approved therapy for short bowel syndrome (SBS) dependent on parenteral support. It promotes intestinal growth and adaptation, reducing the need for intravenous nutrition.

Mechanism of Action

Binds to GLP-2 receptors on intestinal epithelial cells, stimulating mucosal growth, increasing villus height and crypt depth, enhancing nutrient and fluid absorption, and reducing gastric emptying and secretion. The net effect is increased intestinal absorptive capacity.

Benefits

  • Only FDA-approved drug for short bowel syndrome[1]
  • Reduces parenteral nutrition volume requirements by ~30-50%
  • Achieves parenteral nutrition independence in ~20-30% of patients
  • Improves intestinal absorption and mucosal architecture[1]
Not Medical Advice — Research-Reported Information Only

This content is for informational purposes only and does not constitute medical advice.

Teduglutide — Dosing in Published Research

Reported Routes: Subcutaneous injection
0.05 mg/kg SC once daily. Treatment should continue until parenteral nutrition independence is achieved or until no further benefit is observed. Requires baseline and periodic colonoscopy.

The dosing information above is sourced from published research literature and clinical trials. These are not recommendations. Individual responses vary. Always consult a healthcare provider before considering any peptide-based therapy.

Side Effects

  • Abdominal pain and distension
  • Nausea and vomiting
  • Upper respiratory tract infection
  • Injection site reactions
  • Potential for intestinal polyp growth (requires colonoscopic surveillance)
  • Fluid overload and congestive heart failure risk

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Teduglutide is FDA-approved and available by prescription. Licensed telehealth providers can evaluate if it's right for you.

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Approved Treatment Routing

Teduglutide in PeptideScholar's current approved-treatment dataset

Teduglutide is currently modeled on this site as an approved treatment path for: Short bowel syndrome in adult and pediatric patients who are dependent on parenteral support. Brand names in the current dataset: Gattex.

Validation Note
This block reflects the site's current structured treatment data and internal routing logic. It is not a substitute for checking current prescribing, labeling, payer, or local regulatory details.
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Research & Evidence

RCTGut, 2005

Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients.

Teduglutide 0.10 mg/kg/day significantly improved intestinal absorption and reduced stool wet weight vs placebo in SBS patients over 21 days

PMID: 16099790

References

  1. 1. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients.. Gut, 2005. “Teduglutide 0.10 mg/kg/day significantly improved intestinal absorption and reduced stool wet weight vs placebo in SBS patients over 21 days” [PMID: 16099790]

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GLP-1 Support Essentials

Products to help manage side effects and optimize outcomes during treatment.

LMNT Electrolyte Packets

Sodium-focused electrolytes to prevent dehydration and fatigue common in early GLP-1 therapy.

$30–45View on Amazon

High-Protein Shakes (30g)

Convenient protein shakes to maintain muscle mass on reduced GLP-1 caloric intake.

$28–42View on Amazon

Metamucil Fiber Supplement

Soluble fiber powder to manage constipation and GI side effects during GLP-1 treatment.

$20–30View on Amazon

Vitamin B12 (Methylcobalamin 1000mcg)

GLP-1 agonists can reduce B12 absorption over time — methylcobalamin is the most bioavailable form.

$10–20View on Amazon

Ginger Chews for Nausea

Natural nausea relief for the dose-escalation adjustment period, particularly weeks 1–4.

$8–15View on Amazon

Unflavored Whey Protein Isolate

Preserve lean mass without excess carbs or calories when appetite is suppressed.

$35–60View on Amazon

Amazon affiliate links — we may earn a small commission at no extra cost to you. See our disclosure.

Progress Tracking Tools

Monitor weight, body composition, and nutrition to maximize results.

Smart WiFi Body Scale

Tracks BMI, body fat %, and muscle mass — essential for monitoring GLP-1 progress over time.

$30–60View on Amazon

Digital Kitchen Food Scale

Precise gram-level portion tracking helps maximize weight loss results on GLP-1 therapy.

$10–20View on Amazon

Protein Shaker Bottle Set

Leak-proof mixing bottles for protein shakes — supports consistent protein intake on a smaller appetite.

$12–25View on Amazon

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Teduglutide FAQ

Medical Disclaimer

This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.

Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.

No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.

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