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Abaloparatide
AFDA ApprovedParathyroid hormone-related protein analog (1-34) · 34 amino acids · Brand: Tymlos
Abaloparatide is a synthetic analog of parathyroid hormone-related protein (PTHrP 1-34) approved by the FDA for osteoporosis in postmenopausal women at high risk of fracture. Like teriparatide, it is an anabolic bone-building agent with a more transient receptor activation profile.
Mechanism of Action
Binds to PTH1 receptors on osteoblasts, stimulating bone formation. As a PTHrP analog with more transient receptor signaling, it preferentially activates bone formation over bone resorption in early treatment, potentially producing faster BMD increases with lower hypercalcemia risk.
Benefits
- Anabolic bone-building agent for severe osteoporosis
- Significant reduction in vertebral and non-vertebral fractures[1]
- Faster early BMD gains than teriparatide in some studies
- Lower incidence of hypercalcemia vs teriparatide
Side Effects
- Hypercalcemia (less frequent than teriparatide)
- Dizziness, nausea, headache
- Palpitations and orthostatic hypotension
- Injection site reactions
- Osteosarcoma risk in rats (black box warning; 2-year limit)
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Abaloparatide in PeptideScholar's current approved-treatment dataset
Abaloparatide is currently modeled on this site as an approved treatment path for: Osteoporosis in postmenopausal women at high risk of fracture. Brand names in the current dataset: Tymlos.
Research & Evidence
Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis.
Abaloparatide followed by alendronate significantly reduced vertebral fractures by 87% and non-vertebral fractures by 52% vs placebo/alendronate sequence over 3 years
PMID: 31674644References
- 1. Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis.. J Clin Endocrinol Metab, 2020. “Abaloparatide followed by alendronate significantly reduced vertebral fractures by 87% and non-vertebral fractures by 52% vs placebo/alendronate sequence over 3 years” [PMID: 31674644]
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Abaloparatide FAQ
Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.
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