Content reviewed by clinical research staff
Evidence graded using the PeptideScholar A-D system
Octreotide
AFDA ApprovedSomatostatin analog · 8 amino acids · Brand: Sandostatin, Sandostatin LAR Depot
Octreotide is a synthetic cyclic octapeptide analog of somatostatin, approved by the FDA for acromegaly, carcinoid tumors, and vasoactive intestinal peptide (VIP)-secreting tumors. It is one of the most important peptide drugs in oncology and endocrinology.
Mechanism of Action
Binds to somatostatin receptors (SSTR2 > SSTR5 > SSTR3), inhibiting secretion of growth hormone, serotonin, gastrin, glucagon, insulin, and vasoactive intestinal peptide. In neuroendocrine tumors, it suppresses hormone hypersecretion and may have antiproliferative effects.
Benefits
Side Effects
- GI symptoms (nausea, bloating, diarrhea, steatorrhea)
- Gallstones and biliary sludge (long-term use)
- Hyperglycemia (inhibits insulin and glucagon)
- Bradycardia and cardiac conduction abnormalities
- Injection site pain (short-acting form)
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Octreotide in PeptideScholar's current approved-treatment dataset
Octreotide is currently modeled on this site as an approved treatment path for: Acromegaly; carcinoid tumors; vasoactive intestinal peptide tumors (VIPomas); control of symptoms related to metastatic neuroendocrine tumors. Brand names in the current dataset: Sandostatin, Sandostatin LAR Depot.
Research & Evidence
Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group.
Octreotide LAR significantly prolonged time to tumor progression (14.3 vs 6.0 months) in metastatic midgut neuroendocrine tumors vs placebo
PMID: 19704057References
- 1. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group.. J Clin Oncol, 2009. “Octreotide LAR significantly prolonged time to tumor progression (14.3 vs 6.0 months) in metastatic midgut neuroendocrine tumors vs placebo” [PMID: 19704057]
Recommended Resources
The Peptide Protocols Handbook
Evidence-based reference guide covering mechanisms, research, and clinical applications.
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Independent lab analysis to verify peptide purity and authenticity.
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GLP-1 Support Essentials
Products to help manage side effects and optimize outcomes during treatment.
LMNT Electrolyte Packets
Sodium-focused electrolytes to prevent dehydration and fatigue common in early GLP-1 therapy.
High-Protein Shakes (30g)
Convenient protein shakes to maintain muscle mass on reduced GLP-1 caloric intake.
Metamucil Fiber Supplement
Soluble fiber powder to manage constipation and GI side effects during GLP-1 treatment.
Vitamin B12 (Methylcobalamin 1000mcg)
GLP-1 agonists can reduce B12 absorption over time — methylcobalamin is the most bioavailable form.
Ginger Chews for Nausea
Natural nausea relief for the dose-escalation adjustment period, particularly weeks 1–4.
Unflavored Whey Protein Isolate
Preserve lean mass without excess carbs or calories when appetite is suppressed.
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Progress Tracking Tools
Monitor weight, body composition, and nutrition to maximize results.
Smart WiFi Body Scale
Tracks BMI, body fat %, and muscle mass — essential for monitoring GLP-1 progress over time.
Digital Kitchen Food Scale
Precise gram-level portion tracking helps maximize weight loss results on GLP-1 therapy.
Protein Shaker Bottle Set
Leak-proof mixing bottles for protein shakes — supports consistent protein intake on a smaller appetite.
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Recommended Reading
Books covering peptide science, longevity research, and biohacking frameworks.
The Peptide Protocols
Comprehensive reference for peptide mechanisms, dosing research, and clinical applications.
Boundless by Ben Greenfield
Covers peptides, nootropics, hormones, and longevity strategies in an optimization framework.
Lifespan by David Sinclair
Evidence-based deep-dive into aging science, directly relevant to longevity peptide research.
The Longevity Paradox
Gut-centric aging research with diet and supplementation protocols for extending healthspan.
Amazon affiliate links — we may earn a small commission at no extra cost to you. See our disclosure.
Octreotide FAQ
Medical Disclaimer
This content is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.
Always consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Do not disregard professional medical advice based on information found on this site.
No claims of therapeutic efficacy are made for substances that are not FDA-approved for the discussed indications. Research citations reflect published findings and do not imply endorsement.
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